GUT DYSBIOSIS WAS INEVITABLE, BUT TOLERANCE WAS NOT: TEMPORAL RESPONSES OF THE MURINE MICROBIOTA THAT MAINTAIN ITS CAPACITY FOR BUTYRATE PRODUCTION CORRELATE WITH SUSTAINED ANTINOCICEPTION TO CHRONIC MORPHINE

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolerance, whereas

Leslie CitromeDepartment of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USAAbstract: Agitation (excessive motor or verbal activity) can be associated with schizophrenia or bipolar mania, and can further escalate into aggressive behavior and potentially lead to injuries in patients and staff.Medications used to treat

Purpose: to study the structure of heart defects in pregnant women, the features of the medico-social portrait, the course of pregnancy and perinatal outcomes in patients with heart defects in the light of pathomorphosis.Material and Methods.A retrospective clinical gumball bere and anamnestic analysis of the medical documentation of 165 patients d

The article briefly presents a few of redken color fusion 7cr the arguments that ground the concept of high security, the cyber process of security management, the main components of the security of national management system, the place and role of gumball bere national security management, the issue of determining optimal security, the mathematica